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St. Kleio Academy is a very exclusive school: all of the students are clones of famous historical figures such as Beethoven, Queen Elizabeth I, Napoleon, Mozart, and Freud. All of them, that is, except for Shiro Kamiya. As Shiro struggles to adapt to this unusual campus, St. Kleio's first graduate, a clone of John F. Kennedy, is killed. Are the clones doomed to repeat the fate of their genetic progenitors, or can they create their own destinies? And how does a normal boy like Shiro fit in? Twin boys from Clone Nightingale’s distant past are planning to attack the academy, bent on avenging their mother's death. But their plot goes awry, and the brothers are separated. The younger twin attempts to abduct Nightingale, who is now at large. The incident sparks a chain of events that sends all of the clones toward disaster!