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The Chameleon returns with a terrifying new mission - and Mayor J. Jonah Jameson squarely in his sights! And as JJJ's Anti-Spider Squad closes in, Peter Parker gets a brand-new job! Will it bring him closer to the newly returned Mary Jane or push her further away? Then, look out Spidey - the Black Cat's back too, more dangerous than ever! And Raptor seeks revenge against the man he claims killed his family - Ben Reilly, Spider-Man's clone! Plus: Eddie Brock finds a new way to live - as Anti-Venom! Jackpot makes the scene! And Deadpool strikes! Collecting AMAZING SPIDER-MAN (1999) #602-611, SPIDER-MAN: A CHEMICAL ROMANCE, SPIDER-MAN: THE ROOT OF ALL ANNOYANCE, AMAZING SPIDER-MAN PRESENTS: ANTI-VENOM - NEW WAYS TO LIVE #1-3, AMAZING SPIDER-MAN PRESENTS: JACKPOT #1-3, and material from WEB OF SPIDER-MAN (2009) #1 and AMAZING SPIDER-MAN FAMILY #6.